Bromelain

Bromelain is a protease enzyme, introduced in 1957, that comes from the stem and the fruit of the pineapple plant. When taken with meals it aids in the digestion of proteins. When taken on an empty stomach it acts as an anti-inflammatory agent. Historically, bromelain has been used as an

  • anti-inflammatory
  • Diuretic
  • inducer of uterine contractions
  • treatment of sprains, contusions, abscesses, and ulcerations
  • Treatment of sinusitis
  • Removal of eschar in 3rd degree burns

More recent studies have demonstrated in vivo and in vitro that bromelain also has antiedematous, anti-inflammatory, antithrombotic, fibrinolytic, and antioncogenic properties.

  • It has the ability to decrease the production of cytokines, specifically TNF-α, IL-1β, IL-6, and IL-8.
  • It demonstrates the ability to stimulate monocyte/macrophage cytotoxicity.
  • It has been suggested to activate human T cells.
  • Bromelain decreases vascular permeability.
  • Minimizes post-operative edema and ecchymosis.

Two separate randomized double blind studies showed the same efficacy in the treatment of osteoarthritis and mild knee pain as traditional NSAID treatment demonstrating its anti-inflammatory activity.