Mangosteen

This is a tropical tree native to Asia. Primarily the fruit hulls are

used for medicinal purposes. In the US, mangosteen is becoming commonly associated with cancer treatment and as a general antioxidant.

It contains many active phytochemicals. One set of these compounds, the prenylated xanthones, has been well researched. There are several in vitro studies showing anti-bacterial, anti-cancer, anti-fungal and anti-inflammatory effects.

• Polysaccharides in the extract can stimulate phagocytic cells and kill intracellular bacteria by stimulating superoxide production.

• Studies have shown a strong inhibitory effect on Propionibacterium acnes and Staphylococcus epidermidis demonstrating the anti-bacterial efficacy

In human breast adenocarcinoma cells, it was observed to have an antiproliferative activity.

Individual Components:

• Α-mangostin

  • Has shown to be a histominergic blocking agent

  • Had indicated non-competitive inhibition of HIV-1 protease

  • Potent antibacterial activity against MRSA and MSSA

  • Thought to inhibit human leukemia cell line HL60 by halting cell growth through apoptosis induced by mitochrondrial damage.

• Β-mangostin

• γ-mangostin

  • A serotonuric receptor blocking agent

  • Non-competitive inhibitor of HIV-1 protease

• Garcinone-E-methoxy-beta-mangostin

  • Demonstrated potent cytotoxic effects on all HCC cell lines as well as other gastric and lung cancer cells.

• 3-hydroxyl-4-geranyl-5-menthoxbiphenyl