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Nutrition Label and BibliographyNutrition Label
BibliographyGonzales, G.F., Cardova, A., Gonzales, C., et al. Lepidium meyenii (Maca) Improved Semen Parameters in Adult Men. Asain J Androl 2001; 3(3): 231-233. Gonzales, G.F., Cardova A., Gonzales, C., et at. Effect of Lepidium meyenii (Maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia 2002; 34(6): 367-372. Gonzales, G.F., Maranda, S., Nieto, J., et al. Red Maca (Lepidium meyenii) reduced prostate size in rats. Reprod Biol Endocrinol 2005; 3(1):5. McKay, D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev 2004; 9(1):4-16. Miller, M.J., Ahmed, S., Bobrowski, P., et al. The chondroprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med 2006;6:13. Piacente, S., Carbone, V., Plaza, A., et al. Investigation of the tuber constituents of Maca (Lepidium meyenii WALP). J Agric Food Chem 2002; 50(20): 5621-5625. Valentova, K., Ulrichova, J. Small anthus sonchifolius and Lepidium meyenii- prospective Andean crops for the prevention of chronic diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czeck Repub 2003; 147(2): 119-131. Zhang, Y., Yu, L., Ao, M., et al. Effects of ethanol extract of Lepidium meyenii Walp on osteoporosis in ovariectiomized rat. J Ethropharmacol 2006; 105(1-2): 274-279. Ayehunie, S., Belay, A., Baba, T.W., and Ruprecht R.M. Inhibition of HIV-1 replication by aqueous extracts of spirulina platensis (Arthrospira plantensis). J. Acquir. Imune Defic. Syndr. Hum. Retroviral 5-1-1998; 18(1): 7-12. Balachandran, P., Pugh, N.D., Ma, G., and Pasco, D.S. Toll-like receptor 2-dependent activation of monocytes by spirulina polysaccharide and its immune enhancing action in mice. Int. Immunopharmacol 12-5-2006; 6(12): 1808-1814. Bogatov, N.V. Selenium deficiency and its dietary correction in patients with Irritable Bowel Syndrome and Chronic Catarrhal Colitis. Vopr.Pitan. 2007; 76(3): 35-39. Chamorro, G., Salazar, M., Favila, L., Bourges, H. Update of the pharmacology of Spirulina (Arthrospira), an unconventional Food. Arch. Latinoam. Nutr. 2002; 52(3): 232-240. Farooq, S.M., Asokan, D., Sakthivel, R., Kalaiselvi, P., and Varalakshmi, P. Salubrious effect of c-phycocyanin against oxalate-mediated renal cell injury. Clin Chim. Acta 2004; 348(1-2): 19-205. Gonzales, de Rivera, Miranda-Zarrura, R., Diaz-Zagoya, J.C., and Juarez-Oropera, M.A. Preventive effect on spirulina maxima on the fatty liver induced by a fructose-rich diet in the rat, a preliminary report. Life Sci 1993; 53(1): 57-61. Gizanna, R., Polotsky, A., Phan, P.V. Immolina a high-molecular-weight polysaccharide fraction of spirulina, enhances chemokine expression in human monocytes THP-1 cells. J. Altern Complement Med 2006; 12(5): 429-435. Han, L.K., Li, D. X., Xiang, L., Gong, X.J., Kondo, Y., Suzuki, I., an Okuda, H. Isolation of pancreatic lipase activity-inhibitory component of spirulina plantensis and it reduced postprandial triacylglycerolemia. Yakugaku Zasshi 2006; 126(1): 43-49. Hayashi, K., Hayashi, T., and Kojima, I. A natural sulfated polysaccharide, calcium spirulan, isolated from spirulina platensis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities. AIDS res Hum Retroviruses 10-10-1996; 12(15): 1463-1471. Ionov, V.A. and Basgva, M.M. Use of blue-green micro-seaweed Spirulina platensis for the correction of lipid and hemostatic disturbances in patients with ischemic heart disease. Vopr.Pitan. 2003; 72(6): 28-31. Ozdemir, G., Kurabay, N.V., Dalay, M.C., and Pazarbasi, G. Antibacterial activity of volatile component and various extracts of Spirulina plantensis. Phytother. Res. 2004; 18(9): 754-757. Roy, K.R., Arunasree, K.M., Reddy, M.P., Dheerai, B., Reddy, G.V. and Reddanna, P. Alteration of mitochondrial membrane potential by spirulina plantensis c-phycocyanin induces apoptosis in the docorubicin-resistant human-hepatocellular-carcinoma cell line Hep62. Biotechnol. Appl Biochem 2007; 47(Pt3): 159-167. Morimoto T, Nagatsu A, Murakami N, et al. Anti-tumour-promoting glyceroglycolipids from the green alga, Chlorella vulgaris. Phytochemistry 1995;40(5):1433-1437. Merchant RE, Andre CA. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med 2001;7(3):79-91. Merchant RE, Carmack CA, Wise CM. Nutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study. Phytother Res 2000;14(3):167-173. Merchant RE, Carmack CA, Wise CM. Nutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study. Phytother Res 2000;14(3):167-173. Kralovec JA, Metera KL, Kumar JR, et al. Immunostimulatory principles from Chlorella pyrenoidosa--part 1: isolation and biological assessment in vitro. Phytomedicine 2007;14(1):57-64. Samuels, R., Mani, U.V., Iyer, U.M. and Nayak, U.S. Hypocholesterolemic effect of Spirulina in patients with hyperlipidemic nephrotic syndrome. J Med Food 2002; 5(2); 91-96. Subhashini, J., Mahipal, S.V., Reddy, M.C., Malilarjuna, Reddy, M., Rachamallu, A., and Reddanna, P. Molecular mechanisms in c-phycocyanin induced apoptosis in human chronic myeloid leukemia cell line k-562. Biochem. Pahrmacol. 8-1-2004;68(3): 452-462. Pugh N, Ross SA, ElSohly HN, et al. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa. Planta Med 2001;67(8):737-742. Wu LC, Ho JA, Shieh MC, et al. Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts. J Agric Food Chem 2005;53(10):4207-4212. Yamagishi S, Nakamura K, Inoue H. Therapeutic potentials of unicellular green alga Chlorella in advanced glycation end product (AGE)-related disorders. Med Hypotheses 2005;65(5):953-955. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62(5):471-472. Chanarat P, Chanarat N, Fujihara M, et al. Immunopharmacological activity of polysaccharide from the pericarb of mangosteen garcinia: phagocytic intracellular killing activities. J Med Assoc Thai 1997;80 Suppl 1:S149-S154. Chen SX, Wan M, Loh BN. Active constituents against HIV-1 protease from Garcinia mangostana. Planta Med 1996;62(4):381-382. Chomnawang MT, Surassmo S, Nukoolkarn VS, et al. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. J Ethnopharmacol 2005;101(1-3):330-333. Dharmaratne HR, Piyasena KG, Tennakoon SB. A geranylated biphenyl derivative from Garcinia malvgostana. Nat Prod Res 2005;19(3):239-243. Gopalakrishnan G, Banumathi B, Suresh G. Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. J Nat Prod 1997;60(5):519-524. Ho CK, Huang YL, Chen CC. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 2002;68(11):975-979. Iinuma M, Tosa H, Tanaka T, et al. Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus. J Pharm Pharmacol 1996;48(8):861-865. Matsumoto K, Akao Y, Kobayashi E, et al. Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 2003;66(8):1124-1127. Matsumoto K, Akao Y, Yi H, et al. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg Med Chem 2004;12(22):5799-5806. Moongkarndi P, Kosem N, Luanratana O, et al. Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia 2004;75(3-4):375-377. Nakatani K, Atsumi M, Arakawa T, et al. Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull 2002;25(9):1137-1141. Caceres A, Lopez B, Juarez X, et al. Plants used in Guatemala for the treatment of dermatophytic infections. 2. Evaluation of antifungal activity of seven American plants. J Ethnopharmacol 1993;40(3):207-213. DERSE PH, ELVEHJEM CA. Nutrient content of acerola, a rich source of vitamin C. J Am Med Assoc 1954;156(16):1501. Hanamura T, Hagiwara T, Kawagishi H. Structural and functional characterization of polyphenols isolated from acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem 2005;69(2):280-286. Visentainer JV, Vieira OA, Matsushita M, et al. [Physico-chemical characterization of acerola (Malpighia glabra L.) produced in Maringa, Parana State, Brazil]. Arch Latinoam Nutr 1997;47(1):70-72. Aarsaether, E., Rydningen, M., Einar, Engstad R., and Busund, R. Cardioprotective effect of pretreatment with beta-glucan in coronary artery bypass grafting. Scand Cardiovasc.J 2006;40(5):298-304. Allendorf, D. J., Yan, J., Ross, G. D., Hansen, R. D., Baran, J. T., Subbarao, K., Wang, L., and Haribabu, B. C5a-Mediated Leukotriene B4-Amplified Neutrophil Chemotaxis Is Essential in Tumor Immunotherapy Facilitated by Anti-Tumor Monoclonal Antibody and {beta}-Glucan. J.Immunol. 6-1-2005;174(11):7050-7056. Anon. Beta glucan vs bacterial infections- continuous daily use of yeast-derived beta glucan is questioned. Posit.Health News 2005;Fall (No. 17):22-23. Behall, K. M., Scholfield, D. J., Hallfrisch, J. G., and Liljeberg-Elmstahl, H. G. Consumption of both resistant starch and beta-glucan improves postprandial plasma glucose and insulin in women. Diabetes Care 2006;29(5):976-981. Brown, G. D. and Gordon, S. Immune recognition. A new receptor for beta-glucans. Nature 9-6-2001;413(6851):36-37. Brown, G. D., Taylor, P. R., Reid, D. M., Willment, J. A., Williams, D. L., Martinez-Pomares, L., Wong, S. Y., and Gordon, S. Dectin-1 is a major beta-glucan receptor on macrophages. J.Exp.Med. 8-5-2002;196(3):407-412. Cheung, N. K. and Modak, S. Oral (1-->3),(1-->4)-beta-D-glucan synergizes with antiganglioside GD2 monoclonal antibody 3F8 in the therapy of neuroblastoma. Clin.Cancer Res. 2002;8(5):1217-1223. Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S., and Gordon, S. Dectin-1 mediates the biological effects of beta-glucans. J.Exp.Med. 5-5-2003;197(9):1119-1124. Cheung, N. K., Modak, S., Vickers, A., and Knuckles, B. Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol.Immunother. 2002;51(10):557-564. Choi, J. H., Brummer, E., and Stevens, D. A. Combined action of micafungin, a new echinocandin, and human phagocytes for antifungal activity against Aspergillus fumigatus. Microbes.Infect. 2004;6(4):383-389. Cross, G. G., Jennings, H. J., Whitfield, D. M., Penney, C. L., Zacharie, B., and Gagnon, L. Immunostimulant oxidized beta-glucan conjugates. Int.Immunopharmacol. 2001;1(3):539-550. Demir, G., Klein, H. O., Mandel-Molinas, N., and Tuzuner, N. Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. Int Immunopharmacol. 2007;7(1):113-116. Harler, M. B. and Reichner, J. Increased neutrophil motility by beta-glucan in the absence of chemoattractant. Shock 2001;16(6):419-424. Jenkins, A. L., Jenkins, D. J., Zdravkovic, U., Wursch, P., and Vuksan, V. Depression of the glycemic index by high levels of beta-glucan fiber in two functional foods tested in type 2 diabetes. Eur.J.Clin.Nutr. 2002;56(7):622-628. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369. Akhtar, N. M., Naseer, R., Farooqi, A. Z., Aziz, W., and Nazir, M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study. Clin.Rheumatol. 2004;23(5):410-415. Billigmann, P. [Enzyme therapy--an alternative in treatment of herpes zoster. A controlled study of 192 patients]. Fortschr.Med 2-10-1995;113(4):43-48. Braun, J. M., Schneider, B., and Beuth, H. J. Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis in Germany. In Vivo 2005;19(2):417-421. Desser, L., Rehberger, A., Kokron, E., and Paukovits, W. Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations. Oncology 1993;50(6):403-407. Eckert, K., Grabowska, E., Stange, R., Schneider, U., Eschmann, K., and Maurer, H. R. Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients. Oncol.Rep. 1999;6(6):1191-1199. Glaser, D. and Hilberg, T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets. 2006;17(1):37-41. Hale, L. P. and Haynes, B. F. Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation. J Immunol. 12-15-1992;149(12):3809-3816. Ito, C., Yamaguchi, K., Shibutani, Y., Suzuki, K., Yamazaki, Y., Komachi, H., Ohnishi, H., and Fujimura, H. [Anti-inflammatory actions of proteases, bromelain, trypsin and their mixed preparation (author's transl)]. Nippon Yakurigaku Zasshi 4-20-1979;75(3):227-237. Klein, G., Kullich, W., Schnitker, J., and Schwann, H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006;24(1):25-30. Maurer, H. R. Bromelain: biochemistry, pharmacology and medical use. Cell Mol.Life Sci 2001;58(9):1234-1245. Avakian AV, Amirian SS, Akopian TN, et al. [Use of papain with dimexide and furacillin in the treatment of suppurative wounds]. Klin Khir 1987;(1):48-49. Chudnovskii NA, Rossinskii VI, Zorin NA, et al. [Use of Soviet papain enzyme in the disk-puncture treatment of lumbar osteochondrosis]. Zh Vopr Neirokhir Im N N Burdenko 1980;(5):56-59. View Abstract Chudnovskii NA. [Use of the proteolytic enzyme papain in the treatment of cervical osteochondrosis]. Zh Vopr Neirokhir Im N N Burdenko 1985;(6):43-47. Dawkins G, Hewitt H, Wint Y, et al. Antibacterial effects of Carica papaya fruit on common wound organisms. West Indian Med J 2003;52(4):290-292. Husson J. [Improvement of vitamin B12 deficiency by papain]. Nouv Presse Med 1982;11(48):3575. Karpov SP, Ivanov LI. [Use of papain in treating necrotic and burn wounds]. Voen Med Zh 1979;(9):24-25. Kaz'min AI, Vetrile ST, Grishin IG. [Treatment of Dupuytren's contracture with papain]. Ortop Travmatol Protez 1978;(8):62-67. Korb DR, Greiner JV, Finnemore VM, et al. Treatment of contact lenses with papain. Increase in wearing time in keratoconic patients with papillary conjunctivitis. Arch Ophthalmol 1983;101(1):48-50. Leipner J, Iten F, Saller R. Therapy with proteolytic enzymes in rheumatic disorders. BioDrugs 2001;15(12):779-789. Matinian LA, Nagapetian K, Amirian SS, et al. [Papain phonophoresis in the treatment of suppurative wounds and inflammatory processes]. Khirurgiia (Mosk) 1990;(9):74-76. Allain, H., Schuck, S., Lebreton, S., Strenge-Hesse, A., Braun, W., Gandon, J. M., and Brissot, P. Aminotransferase levels and silymarin in de novo tacrine-treated patients with Alzheimer's disease. Dement.Geriatr.Cogn Disord. 1999;10(3):181-185. Altorjay, I., Dalmi, L., Sari, B., Imre, S., and Balla, G. The effect of silibinin (Legalon) on the the free radical scavenger mechanisms of human erythrocytes in vitro. Acta Physiol Hung. 1992;80(1-4):375-380. Amirghofran, Z., Azadbakht, M., and Karimi, M. H. Evaluation of the immunomodulatory effects of five herbal plants. J Ethnopharmacol. 2000;72(1-2):167-172. Arteel, G., Marsano, L., Mendez, C., Bentley, F., and McClain, C. J. Advances in alcoholic liver disease. Best.Pract.Res.Clin.Gastroenterol. 2003;17(4):625-647. Asghar, Z. and Masood, Z. Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro. Pak.J Pharm Sci 2008;21(3):249-254. Bean, P. The use of alternative medicine in the treatment of hepatitis C. Am Clin Lab 2002;21(4):19-21. Beckmann-Knopp, S., Rietbrock, S., Weyhenmeyer, R., Bocker, R. H., Beckurts, K. T., Lang, W., Hunz, M., and Fuhr, U. Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes. Pharmacol.Toxicol. 2000;86(6):250-256. Benda, L., Dittrich, H., Ferenzi, P., Frank, H., and Wewalka, F. [The influence of therapy with silymarin on the survival rate of patients with liver cirrhosis (author's transl)]. Wien.Klin.Wochenschr. 10-10-1980;92(19):678-683. Berkson, B. M. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin 10-15-1999;94 Suppl 3:84-89. Bettini, R. and Gorini, M. [Use of ursodeoxycholic acid combined with silymarin in the treatment of chronic ethyl-toxic hepatopathy]. Clin.Ter. 2002;153(5):305-307. Bhatia, N., Zhao, J., Wolf, D. M., and Agarwal, R. Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin. Cancer Lett. 12-1-1999;147(1-2):77-84. Bhatia, N. and Agarwal, R. Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate 2-1-2001;46(2):98-107. Bilia, A. R., Bergonzi, M. C., Gallori, S., Mazzi, G., and Vincieri, F. F. Stability of the constituents of Calendula, milk-thistle and passionflower tinctures by LC-DAD and LC-MS. J Pharm Biomed.Anal. 10-15-2002;30(3):613-624. Buzzelli, G., Moscarella, S., Giusti, A., Duchini, A., Marena, C., and Lampertico, M. A pilot study on the liver protective effect of silybinphosphatidylcholine complex (IdB1016) in chronic active hepatitis. Int.J Clin Pharmacol.Ther.Toxicol. 1993;31(9):456-460. Deak, G., Muzes, G., Lang, I., Niederland, V., Nekam, K., Gonzalez-Cabello, R., Gergely, P., and Feher, J. [Immunomodulator effect of silymarin therapy in chronic alcoholic liver diseases]. Orv.Hetil. 6-17-1990;131(24):1291-1296. Chu, S. C., Chiou, H. L., Chen, P. N., Yang, S. F., and Hsieh, Y. S. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol.Carcinog. 2004;40(3):143-149. Dehmlow, C., Erhard, J., and de Groot, H. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology 1996;23(4):749-754. Dehmlow, C., Murawski, N., and de Groot, H. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sci 1996;58(18):1591-1600. Donadoni, M. L., Gavezzotti, R., Borella, F., Di Giulio, A. M., and Gorio, A. Experimental diabetic neuropathy. Inhibition of protein mono-ADP-ribosylation prevents reduction of substance P axonal transport. J Pharmacol Exp.Ther. 1995;274(1):570-576. Feher, J., Deak, G., Muzes, G., Lang, I., Niederland, V., Nekam, K., and Karteszi, M. [Liver-protective action of silymarin therapy in chronic alcoholic liver diseases]. Orv.Hetil. 12-17-1989;130(51):2723-2727. Feher, J. and Lengyel, G. [Silymarin in the treatment of chronic liver diseases: past and future]. Orv.Hetil. 12-21-2008;149(51):2413-2418. Ferenci, P., Dragosics, B., Dittrich, H., Frank, H., Benda, L., Lochs, H., Meryn, S., Base, W., and Schneider, B. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol. 1989;9(1):105-113. Gaedeke, J., Fels, L. M., Bokemeyer, C., Mengs, U., Stolte, H., and Lentzen, H. Cisplatin nephrotoxicity and protection by silibinin. Nephrol.Dial.Transplant. 1996;11(1):55-62. Gatti, G. and Perucca, E. Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers. Int.J Clin Pharmacol.Ther. 1994;32(11):614-617. Gorio, A., Donadoni, M. L., Finco, C., Borella, F., and Di Giulio, A. M. Alterations of protein mono-ADP-ribosylation and diabetic neuropathy: a novel pharmacological approach. Eur.J Pharmacol 9-5-1996;311(1):21-28. Gurley, B., Hubbard, M. A., Williams, D. K., Thaden, J., Tong, Y., Gentry, W. B., Breen, P., Carrier, D. J., and Cheboyina, S. Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. J Clin Pharmacol 2006;46(2):201-213. Kalmar, L., Kadar, J., Somogyi, A., Gergely, P., Csomos, G., and Feher, J. Silibinin (Legalon-70) enhances the motility of human neutrophils immobilized by formyl-tripeptide, calcium ionophore, lymphokine and by normal human serum. Agents Actions 1990;29(3-4):239-246. Katiyar, S. K. Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (Review). Int.J Oncol. 2005;26(1):169-176. Kittur, S., Wilasrusmee, S., Pedersen, W. A., Mattson, M. P., Straube-West, K., Wilasrusmee, C., Lubelt, B., and Kittur, D. S. Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture. J Mol.Neurosci. 2002;18(3):265-269. Lang, I., Deak, G., Nekam, K., Muzes, G., Gonzalez-Cabello, R., Gergely, P., and Feher, J. Hepatoprotective and immunomodulatory effects of antioxidant therapy. Acta Med Hung. 1988;45(3-4):287-295. Lee, D. G., Kim, H. K., Park, Y., Park, S. C., Woo, E. R., Jeong, H. G., and Hahm, K. S. Gram-positive bacteria specific properties of silybin derived from Silybum marianum. Arch Pharm Res 2003;26(8):597-600. Li, L. H., Wu, L. J., Zhou, B., Wu, Z., Tashiro, S., Onodera, S., Uchiumi, F., and Ikejima, T. Silymarin prevents UV irradiation-induced A375-S2 cell apoptosis. Biol.Pharm.Bull. 2004;27(7):1031-1036. Luper, S. A review of plants used in the treatment of liver disease: part 1. Altern.Med.Rev. 1998;3(6):410-421. Maggs, J. R. and Chapman, R. W. An update on primary sclerosing cholangitis. Curr.Opin.Gastroenterol. 2008;24(3):377-383. Magliulo, E., Gagliardi, B., and Fiori, G. P. [Results of a double blind study on the effect of silymarin in the treatment of acute viral hepatitis, carried out at two medical centres (author's transl)]. Med Klin. 7-14-1978;73(28-29):1060-1065. Manna, S. K., Mukhopadhyay, A., Van, N. T., and Aggarwal, B. B. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N- terminal kinase, and apoptosis. J Immunol. 12-15-1999;163(12):6800-6809. Mokhtari, M. J., Motamed, N., and Shokrgozar, M. A. Evaluation of silibinin on the viability, migration and adhesion of the human prostate adenocarcinoma (PC-3) cell line. Cell Biol Int 2008;32(8):888-892. Ramasamy, K. and Agarwal, R. Multitargeted therapy of cancer by silymarin. Cancer Lett 10-8-2008;269(2):352-362. Schroder, F. H., Roobol, M. J., Boeve, E. R., de Mutsert, R., Zuijdgeest-van Leeuwen, S. D., Kersten, I., Wildhagen, M. F., and van Helvoort, A. Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement. Eur Urol 2005;48(6):922-930. Sonnenbichler, J., Scalera, F., Sonnenbichler, I., and Weyhenmeyer, R. Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells. J Pharmacol Exp Ther 1999;290(3):1375-1383. Tyagi, A., Agarwal, C., Harrison, G., Glode, L. M., and Agarwal, R. Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis 2004;25(9):1711-1720. Tyagi, A. K., Agarwal, C., Singh, R. P., Shroyer, K. R., Glode, L. M., and Agarwal, R. Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells. Biochem.Biophys Res.Commun. 12-26-2003;312(4):1178-1184. Tyagi, A. K., Agarwal, C., Chan, D. C., and Agarwal, R. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol Rep. 2004;11(2):493-499. Wilasrusmee, C., Kittur, S., Shah, G., Siddiqui, J., Bruch, D., Wilasrusmee, S., and Kittur, D. S. Immunostimulatory effect of Silybum Marianum (milk thistle) extract. Med Sci.Monit. 2002;8(11):BR439-BR443. Zima, T., Kamenikova, L., Janebova, M., Buchar, E., Crkovska, J., and Tesar, V. The effect of silibinin on experimental cyclosporine nephrotoxicity. Ren Fail. 1998;20(3):471-479. Akesson, C., Lindgren, H., Pero, R. W., Leanderson, T., and Ivars, F. An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death. Int.Immunopharmacol. 2003;3(13-14):1889-1900. Allen-Hall, L., Cano, P., Arnason, J. T., Rojas, R., Lock, O., and Lafrenie, R. M. Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha. J Ethnopharmacol 1-19-2007;109(2):312-317. Bacher, N., Tiefenthaler, M., Sturm, S., Stuppner, H., Ausserlechner, M. J., Kofler, R., and Konwalinka, G. Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells. Br J Haematol. 2006;132(5):615-622. Ccahuana-Vasquez, R. A., Santos, S. S., Koga-Ito, C. Y., and Jorge, A. O. Antimicrobial activity of Uncaria tomentosa against oral human pathogens. Braz.Oral Res 2007;21(1):46-50. Cheng, A. C., Jian, C. B., Huang, Y. T., Lai, C. S., Hsu, P. C., and Pan, M. H. Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells. Food Chem Toxicol 2007;45(11):2206-2218. De Martino, L., Martinot, J. L., Franceschelli, S., Leone, A., Pizza, C., and De, Feo, V. Proapoptotic effect of Uncaria tomentosa extracts. J Ethnopharmacol 8-11-2006;107(1):91-94. Frackowiak, T., Baczek, T., Roman, K., Zbikowska, B., Glensk, M., Fecka, I., and Cisowski, W. Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40). Z Naturforsch.[C.] 2006;61(11-12):821-826. Garcia Prado, E., Garcia Gimenez, M. D., De la Puerta, V., Espartero Sanchez, J. L., and Saenz Rodriguez, M. T. Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine 2007;14(4):280-284. Goncalves, C., Dinis, T., and Batista, M. T. Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry 2005;66(1):89-98. Hardin, S. R. Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract 2007;13(1):25-28. Heitzman, M. E., Neto, C. C., Winiarz, E., Vaisberg, A. J., and Hammond, G. B. Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae). Phytochemistry 2005;66(1):5-29. Keplinger, K., Laus, G., Wurm, M., Dierich, M. P., and Teppner, H. Uncaria tomentosa (Willd.) DC.--ethnomedicinal use and new pharmacological, toxicological and botanical results. J.Ethnopharmacol. 1999;64(1):23-34. Lamm, S., Sheng, Y., and Pero, R. W. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine 2001;8(4):267-274. Lemaire, I., Assinewe, V., Cano, P., Awang, D. V., and Arnason, J. T. Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (una de gato). J.Ethnopharmacol. 1999;64(2):109-115. Mammone, T., Akesson, C., Gan, D., Giampapa, V., and Pero, R. W. A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. Phytother Res 2006;20(3):178-183. Mehta, K., Gala, J., Bhasale, S., Naik, S., Modak, M., Thakur, H., Deo, N., and Miller, M. J. Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC.Complement Altern.Med 2007;7:34. Miller, M. J., Angeles, F. M., Reuter, B. K., Bobrowski, P., and Sandoval, M. Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis. BMC.Complement Altern Med 2001;1:11. Mur, E., Hartig, F., Eibl, G., and Schirmer, M. Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol 2002;29(4):678-681. Pero, R. W., Amiri, A., Sheng, Y., Welther, M., and Rich, M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine 2005;12(4):255-263. Pilarski, R., Zielinski, H., Ciesiolka, D., and Gulewicz, K. Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC. J Ethnopharmacol 3-8-2006;104(1-2):18-23. Piscoya, J., Rodriguez, Z., Bustamante, S. A., Okuhama, N. N., Miller, M. J., and Sandoval, M. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm.Res 2001;50(9):442-448. Riva, L., Coradini, D., Di Fronzo, G., De, Feo, V, De Tommasi, N., De Simone, F., and Pizza, C. The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Res 2001;21(4A):2457-2461. Rizzi, R., Re, F., Bianchi, A., De, Feo, V, De Simone, F., Bianchi, L., and Stivala, L. A. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. J.Ethnopharmacol. 1993;38(1):63-77. Sandoval-Chacon, M., Thompson, J. H., Zhang, X. J., Liu, X., Mannick, E. E., Sadowska-Krowicka, H., Charbonnet, R. M., Clark, D. A., and Miller, M. J. Antiinflammatory actions of cat's claw: the role of NF-kappaB. Aliment.Pharmacol.Ther. 1998;12(12):1279-1289. Sandoval, M., Charbonnet, R. M., Okuhama, N. N., Roberts, J., Krenova, Z., Trentacosti, A. M., and Miller, M. J. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic.Biol.Med. 7-1-2000;29(1):71-78. Sandoval, M., Okuhama, N. N., Zhang, X. J., Condezo, L. A., Lao, J., Angeles', F. M., Musah, R. A., Bobrowski, P., and Miller, M. J. Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine 2002;9(4):325-337. Senatore, A., Cataldo, A., Iaccarino, F. P., and Elberti, M. G. [Phytochemical and biological study of Uncaria tomentosa]. Boll Soc Ital Biol Sper 1989;65(6):517-520. Sheng, Y., Li, L., Holmgren, K., and Pero, R. W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8(4):275-282. Wurm, M., Kacani, L., Laus, G., Keplinger, K., and Dierich, M. P. Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor. Planta Med 1998;64(8):701-704. |