Papain

Papain is an enzyme found in papaya (carica papaya) fruit latex. It is a member of the papain family of cysteine proteinases that includes:

  • Chymopapain
  • Caricain
  • Bromelain
  • Actindin
  • Ficin
  • Aleurain
  • lysosomal cathepsins.

In rheumatologic disorders, when taken orally, it has shown to have an analgesic and anti-inflammatory effect. When taken orally it has also been shown to improve the absorption of vitamin B12.

In standard western medical care, papain-containing debridement agents are commonly used to remove necrotic or dead tissue and slough in burns, post-operative wounds, pilonidal cyst, carbuncles, trauma wounds, infected wounds, chronic lesions, varicose and diabetic ulcers.  It contains anti-bacterial properties against gram positive and gram negative bacteria.  

Papain
is also used in the treatment of osteochondrosis, Dupuytren’s contracture, and is used to decrease papillary conjunctivitis in people who wear contact lenses.